Psychological effects of ketamine

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Background: The psychosis-inducing effect of ketamine is important evidence supporting the glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not been described systematically.

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Aim: To examine the effects of ketamine in healthy people using a structured psychiatric interview. : Ketamine induced a range of perceptual distortions, but not hallucinations. Referential ideas were seen in nearly half the sample. There were only mild and infrequent ratings on the thought disorder scale.

Affective flattening and alogia were seen in some volunteers. Conclusions: Ketamine does not reproduce the full picture of schizophrenia. The main point of similarity concerns referential thinking. Phenomena resembling negative symptoms are also seen, but the distinction of these from the drug's sedative effects requires further elucidation. Please enable it to take advantage of the complete set of features!

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RSS Link Copy. Full text links Cite Display options Display options. Abstract Background: The psychosis-inducing effect of ketamine is important evidence supporting the glutamate hypothesis of schizophrenia. Figures Fig. See this image and copyright information in PMC. Comment in Psychopathological consequences of ketamine.

Stone JM, et al. Br J Psychiatry.

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PMID: No abstract available. Similar articles Psychopathological consequences of ketamine. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis. Corlett PR, et al.

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Arch Gen Psychiatry. Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study. Deakin JF, et al. Prediction error, ketamine and psychosis: An updated model. J Psychopharmacol. Epub May Psychiatric safety of ketamine in psychopharmacology research. Perry EB Jr, et al. Psychopharmacology Berl. Epub Feb PMID: Review. See all similar articles.

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Cited by 61 articles A continuum hypothesis of psychotomimetic rapid antidepressants. Haarsma J, et al. Brain Neurosci Adv. Alshammari TK. Berkovitch L, et al. J Neurosci. Epub Nov PMID: Association between circulating levels of C-reactive protein and positive and negative symptoms of psychosis in adolescents in a general population birth cohort. Khandaker GM, et al. J Psychiatr Res. Online ahead of print. Ketamine reduces temporal expectation in the rhesus monkey.

Epub Nov 9. See all "Cited by" articles. MeSH terms Adult Actions. Brief Psychiatric Rating Scale Actions. Female Actions. Humans Actions. Infusions, Parenteral Actions. Interview, Psychological Actions. Male Actions. Middle Aged Actions. Ketamine Actions. PubMed Central. Copy Download.

Psychological effects of ketamine

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Ketamine can cause hallucinations and can affect the body’s senses.